1. Chemical Structure (See Left), SCXRD, XRD, pKa Rule indicated that the Febuxostat and Telmisartan can form a Salt (No Salts reported for both forms even with highly acidic/basic salt formers)
2. Orthogonal Investigation Carried Out
- FTIR: Presence of Carbonyl Group (Except Shift) and Absence of “M” Shaped Canine Teeth Carboxylate Peak between 1650 cm-1 and 1360 cm-1) indicates Cocrystal Formation
- Raman: Presence of C=C (Febuxostat) and C=N (Telmisartan) in Cocrystal as Doublet indicates absence of proton transfer (C=NH+ or salt formation)
Delivery Impact
Ganesan T, Muthudoss P, Voguri RS, Ghosal S, Ann EY, Kwok J, Shahnawaz SS, Omar MF, Allada R, See HH. A new Febuxostat-Telmisartan Drug-Drug Cocrystal for Gout-Hypertension Combination Therapy. Journal of pharmaceutical sciences. 2022 Dec 1;111(12):3318-26.