Case Study 5: Febuxostat-Telmisartan Cocrystal

1. Chemical Structure (See Left), SCXRD, XRD, pKa Rule indicated that the Febuxostat and Telmisartan can form a Salt (No Salts reported for both forms even with highly acidic/basic salt formers)

2. Orthogonal Investigation Carried Out

  • FTIR: Presence of Carbonyl Group (Except Shift) and Absence of “M” Shaped Canine Teeth Carboxylate Peak between 1650 cm-1 and 1360 cm-1) indicates Cocrystal Formation
  • Raman: Presence of C=C (Febuxostat) and C=N (Telmisartan) in Cocrystal as Doublet indicates absence of proton transfer (C=NH+ or salt formation)

Ganesan T, Muthudoss P, Voguri RS, Ghosal S, Ann EY, Kwok J, Shahnawaz SS, Omar MF, Allada R, See HH. A new Febuxostat-Telmisartan Drug-Drug Cocrystal for Gout-Hypertension Combination Therapy. Journal of pharmaceutical sciences. 2022 Dec 1;111(12):3318-26.

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